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INTERNSHIP PROGRAM OF BIODISCOVERY GROUP

Jan 8, 2018 - Jun 30, 2018
09:00 PM - 05:00 PM
BioDiscovery Group, 24th Main Road 1st Phase,J P Nagar
Bengaluru,India View map →
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BioDiscovery Group is offering internship of 3 & 6 months at our Bengaluru Office, Karnataka, India. The internship program starts from January 2018 and the topics in which we are providing internship are:

  • NGS Data Analysis
  • Drug Discovery Technology- Bioinformatics, Docking & MD Simulations
  • Immunoinformatics & Vaccine Design

The salient features of the program are-

  • The fee for the 3 month Internship program includes training, research, field work and experience of working in a Biotech organization.
  • The fee for the 6 month Internship program includes training, a novel research project with International publication, field work and experience of working in a Biotech organization.
  • The fee for this internship program can be paid in two installments.
  • The students will also get exposure of travelling in India and Foreign countries with the team of BioDiscovery Group to assist in conducting workshops & training programs. 
  • As we always value the talent hence there is a good chance of recruitment of the trainees.

The subtopics under each technology are as follows:

Next Generation Sequencing Data Analysis

  • Basic Terminologies
  • Introduction to file types in NGS
  • Database and file formats in NGS
  • NCBI Genomics Library
  • NCBI Resources Used In Next Generation Sequencing
  • Blasting into SRA
  • Preprocessing of raw reads: quality control (FastQC), adapter clipping, quality trimming
  • Mapping output (SAM/BAM format)
  • Retrieving sequence from SRA (NCBI toolkit)
  • Raw sequence files (FASTQ format)
  • Finding NGS data from PUBMED SRA link
  • DNA and RNA-seq NGS read alignment
  • Visualization of mapped reads
  • Germline variant calling
  • Somatic variant calling and de novo mutation
  • Variant Filtering and annotation
  • Variant association and prioritization
  • Big Data Analysis and visualization

Drug Discovery Technology- Bioinformatics, Docking & MD Simulations

  • In-silico generation of ligands by ChemSketch
  • Pharmacophore Detection.
  • Modification of Ligand.
  • Conversion of Mol files to Pdb files by Open Babel
  • Homology Modelling
  • Protein optimization & Energy Minimization by SPDBV
  • Molecular Docking by MGL Tools | Creation of Grid Parameter & Dock Parameter files by AutoDock Software
  • Running the Docking Algorithm by Cygwin
  • Selection of potent inhibitors on the basis of binding energies(delta G) and Lipinski's Rule of 5
  • Creating docking complex
  • Structure Analysis- Protein & ligand complex H-bond interaction by UCSF Chimera
  • Drug Optimisation
  • Making a protein structure file.
  • Solvating the protein in a water box- parameter generation for the protein or the small molecule
  • Adding ions to the solvated protein.
  • NAMD configuration file.
  • Minimization and equilibration.
  • Simulations parameters and running the simulations.
  • Analysis of the simulations.

Immunoinformatics & Vaccine Design

  • Introduction to Immunoinformatics
  • Role of Immunoinformatics in advance medicine field.
  • Practical overview
  • Immunome browser
  • Antigenic protein retrieval
  • Functional analysis
  • Introduction to computational vaccine design.
  • Types of vaccine design and application.
  • Practical overview.
  • Case study
  • Retrieval of sequence
  • Antigenicity prediction
  • Allergy prediction
  • Functional analysis
  • Protein structure analysis
  • Modeling
  • Antigen active site
  • Population coverage
  • Visualization of antibody

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